Basically ever time I dump an NES game there's about a 20 minute re-learning experience because of, I think, some bugs in the software, but it works on every Windows version I've thrown it at. Like Xerxes is saying, if you hit play mode, ignore the warning saying that copynes isn't plugged in, say ok, and the game should appear on your TV. (then wiggle it around a bunch until it actually reads since it's, you know, an NES).
-------------------------